SINCE World war 2, medical science has progressed to a stage where competitive medications are around to treat precisely the same ailment in various people. This is simply not pretty much brands (which is a trade issue) but generic drugs (which is a scientific issue). Within this report, we shall go through the various factors that decide selecting a certain drug.
Safety: These sub-criteria should be considered underneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even if they have certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but include the possibility side-effect of addiction.
* Long-term safety: http://medicationdirectory.com could be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and many chemicals reply to make a different chemical, that have an effect that will harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other, have certain effects on one or maybe more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually create the same impact on precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both medicine is more serious.
Tolerability: A medicine could be effective but not tolerable by all patients. Example: Allergies to certain drugs in some people. Short-term and long-term tolerability have to be taken into account. Efficacy: A medicine just isn’t equally good at all patients. For example, some patients with depression or anxiety attacks experience rest from escitalopram, but there are many that do not, who therefore have to be prescribed a different anti-depressant. The rate of start of therapeutic action is a crucial step to be considered too.
Cost: Cost doesn’t imply the expense of purchase of a particular medicine alone. It will also cover the expense of treatments for a complication that will arise by using a different drug. Example: In the one who insists on taking alcohol and yet needs to be treated for depression is often administered an SSRI drug since these drugs don’t potentiate the consequences of alcohol, whereas another number of anti-depressants (including tricyclics) might cause a fresh problem in such patients, which will have to have a various and expensive treatment. Therefore, it’s preferable to prescribe the more costly escitalopram rather than a cheaper tricyclic such patients.
Simple treatment: The easiest mode of administration is preferred. If you have a selection between an injection and oral administration, the second is preferred if your efficacy of both modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are key point to make a decision simple treatment.
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