SINCE World war 2, medical science has progressed to a stage where competitive medications are around to treat precisely the same ailment in different people. This is simply not pretty much brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall glance at the various factors that decide the selection of a certain drug.
Safety: The next sub-criteria has to be considered underneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is often a particular drug even if it’s certain side-effects as long as the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the potential side-effect of addiction.
* Long-term safety: medicine directory may be safe in short-term treatment, but wait, how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and lots of chemicals answer make a different chemical, which has an effect that may harm the individual or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, independent of one another, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is determined by for its metabolism. This causes an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, two or more drugs actually make the same relation to precisely the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both the medicines are more intense.
Tolerability: A medicine may be effective however, not tolerable by all patients. Example: Allergies to certain drugs in a few people. Short-term and long-term tolerability should be considered. Efficacy: A medicine is just not equally great at all patients. For instance, some patients with depression or anxiety disorders experience respite from escitalopram, but there are many that do not, who therefore should be prescribed some other anti-depressant. The speed of start of therapeutic action is an important step to be regarded as too.
Cost: Cost does not necessarily mean the cost of acquiring some medicine alone. It ought to also cover the cost of management of a complication that may arise while using some other drug. Example: Inside a individual that insists on taking alcohol but needs to be treated for depression is usually administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) may cause a brand new symptom in such patients, which will need a different and expensive treatment. Therefore, it’s preferable to prescribe the more expensive escitalopram rather than cheaper tricyclic in such patients.
Simple treatment: The simplest mode of administration is preferred. If you have an option between a shot and oral administration, rogues is preferred in the event the efficacy of both the modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to make a decision simple treatment.
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