SINCE Wwii, medical science has progressed to some stage where competitive medications are available to treat exactly the same ailment in several people. This isn’t almost brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall look at the various factors that decide the selection of a selected drug.
Safety: These sub-criteria has to be considered underneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is a particular drug even if it’s certain side-effects providing the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but include the potential side-effect of addiction.
* Long-term safety: medication directory could possibly be safe in short-term treatment, but exactly how safe it can be in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Drugs are chemicals, and many chemicals react to make a different chemical, which has an effect which could harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, independent of one another, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on because of its metabolism. This leads to a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually make the same influence on exactly the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the two drugs are more intense.
Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to particular drugs in some people. Short-term and long-term tolerability must be taken into consideration. Efficacy: A drug just isn’t equally efficient at all patients. For instance, some patients with depression or anxiety attacks experience respite from escitalopram, but there are lots of that don’t, who therefore must be prescribed an alternative anti-depressant. The interest rate of beginning of therapeutic action is a crucial step to be looked at too.
Cost: Cost does not always mean the price tag on purchase of a particular medicine alone. It ought to also cover the price tag on treatment of a complication which could arise while using an alternative drug. Example: In a one who insists on taking alcohol nevertheless must be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (like tricyclics) can cause a fresh overuse injury in such patients, which would demand a different and expensive treatment. Therefore, it’s better to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The easiest mode of administration is preferred. If you find an alternative between a shot and oral administration, rogues is preferred if the efficacy of the two modes can be compared. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are key point to decide simple treatment.
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