Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors determined by each SARM’s chemical structure. Consequently, SARMs lead to anabolic cellular activity while avoiding lots of the negative effects of available today steroid drugs. SARMs have already been studied in the management of breast cancer and cachexia and also have recently been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
To provide the backdrop, mechanisms, current and potential clinical applications, along with risks and advantages of SARMs.
Methods
A literature review was performed in MEDLINE while using the terms selective androgen receptor modulator, hypogonadism, cachexia, cancers of the breast, benign prostatic hyperplasia, libido, and lean body mass. Both investigation and studies were included.
Main Outcome Measure
To perform overview of peer-reviewed literature.
Results
Though there are currently no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential uses of these compounds. Basic research has dedicated to the pharmacokinetics and pharmacodynamics of the agents, demonstrating good availability using a paucity of drug interactions. Early clinical tests have demonstrated potential uses of SARMs inside the treatments for cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good success.
Conclusion
SARMs have several possible clinical applications, with promise for that safe use in treating cachexia, BPH, hypogonadism, cancer of the breast, and cancer of prostate.
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