Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Consequently, SARMs cause anabolic cellular activity while avoiding many of the side effects of now available steroids. SARMs are already studied within the treating cancers of the breast and cachexia and have already been used as performance-enhancing agents. Here, we evaluate and summarize the current literature on SARMs.
Aim
To present the backdrop, mechanisms, current and potential clinical applications, and also risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancers, benign prostatic hyperplasia, libido, and lean muscle mass. Both research and clinical tests were included.
Main Outcome Measure
To finish an assessment peer-reviewed literature.
Results
However, there are still no U.S. Drug and food Agency-approved indications for SARMs, investigators are checking out the potential uses for these compounds. Preliminary research has devoted to the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability which has a paucity of drug interactions. Early clinical studies have demonstrated potential ways to use SARMs from the treating cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancers of the breast, with good results.
Conclusion
SARMs have a lot of possible clinical applications, with promise for that safe use in the treatment of cachexia, BPH, hypogonadism, breast cancer, and prostate cancer.
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