SINCE World war 2, medical science has progressed with a stage where competitive medications are available to treat the identical ailment in numerous people. It’s not just about brands (the industry trade issue) but generic drugs (the industry scientific issue). In this report, we shall go through the various factors that decide selecting a particular drug.
Safety: The following sub-criteria has to be considered within the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is really a particular drug regardless of whether it’s got certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but feature the opportunity side-effect of addiction.
* Long-term safety: medicine directory could be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in case there is prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and a lot of chemicals react to produce a different chemical, which has an effect that could harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same impact on the identical organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly around the brain. Thus, the side-effects of both drugs are more intense.
Tolerability: A drug could be effective however, not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability need to be taken into account. Efficacy: A drug is just not equally effective in all patients. By way of example, some patients with depression or panic disorders experience reduced escitalopram, but there are numerous that don’t, who therefore need to be prescribed another anti-depressant. The interest rate of beginning of therapeutic action is a vital step to be regarded as too.
Cost: Cost does not necessarily mean the price tag on purchase of a certain medicine alone. It should also cover the price tag on management of a complication that could arise while using another drug. Example: Within a individual that insists on taking alcohol yet has to be treated for depression is normally administered an SSRI drug as these drugs don’t potentiate the results of alcohol, whereas another number of anti-depressants (including tricyclics) may cause a whole new problem in such patients, which may need a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than cheaper tricyclic in this patients.
Simple treatment: Most effective mode of administration is preferred. If you have an option between an injection and oral administration, the second is preferred if the efficacy of both modes is comparable. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to decide simple treatment.
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