SINCE World war 2, medical science has progressed with a stage where competitive medications are for sale to treat exactly the same ailment in different people. This is not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). In this report, we shall glance at the various factors that decide picking a a specific drug.
Safety: The following sub-criteria should be considered under the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective is often a particular drug regardless of whether they have certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: directory may be safe in short-term treatment, but exactly how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and a lot of chemicals answer make a different chemical, which has an effect that may harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other person, have certain effects one or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This makes a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two prescription medication is more serious.
Tolerability: A medicine may be effective although not tolerable by all patients. Example: Allergies to a particular drugs in a few people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medicine just isn’t equally efficient at all patients. For example, some patients with depression or panic attacks experience rest from escitalopram, but there are numerous that don’t, who therefore should be prescribed an alternative anti-depressant. The interest rate of oncoming of therapeutic action is a crucial factor to be regarded as too.
Cost: Cost doesn’t imply the expense of acquisition of some medicine alone. It must also cover the expense of treatment of a complication that may arise from utilizing an alternative drug. Example: Within a individual that insists on taking alcohol yet must be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (including tricyclics) may cause a fresh condition in such patients, which would demand a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than cheaper tricyclic in these patients.
Simplicity of treatment: Most effective mode of administration is preferred. If you find an option between an injection and oral administration, rogues is preferred if the efficacy of the two modes can be compared. Or, local application is preferred to the oral route where possible; e.g., antibiotic treatment of eye infections. Dosage and frequency of administration too are a key factor to decide simplicity of treatment.
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