SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat exactly the same ailment in various people. This isn’t almost brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall go through the various factors that decide the selection of a selected drug.
Safety: The subsequent sub-criteria must be considered within the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is often a particular drug even when they have certain side-effects provided that the acuteness of the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: medicationdirectory.com could possibly be safe in short-term treatment, but how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Prescription medication is chemicals, and several chemicals react to make a different chemical, that have an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, outside of the other person, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance of the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) is dependent upon because of its metabolism. This leads to a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually create the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both medicines are more intense.
Tolerability: A medicine could possibly be effective and not tolerable by all patients. Example: Allergies to a particular drugs in most people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medicine isn’t equally good at all patients. As an example, some patients with depression or panic attacks experience respite from escitalopram, but there are many who don’t, who therefore should be prescribed another anti-depressant. The speed of beginning of therapeutic action is a vital step to be looked at too.
Cost: Cost doesn’t imply the expense of buying a particular medicine alone. It should also cover the expense of management of a complication that may arise by using another drug. Example: In a individual that insists on taking alcohol but needs to be treated for depression is normally administered an SSRI drug because these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (like tricyclics) might cause a fresh problem in such patients, which could have to have a different and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram instead of a cheaper tricyclic in this patients.
Simple treatment: The simplest mode of administration is preferred. If there is an option between an injection and oral administration, the second is preferred in the event the efficacy of both modes is analogous. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are an important factor to choose simplicity of treatment.
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